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Sr. Scientist - Assay Development

Company: IBIO
Location: Bryan
Posted on: May 6, 2021

Job Description:

Sr. Scientist - Assay DevelopmentiBio is a global leader in plant-based biologics manufacturing. Our FastPharming System combines vertical farming, automated hydroponics, and glycan engineering technologies to rapidly deliver gram quantities of high quality monoclonal antibodies, vaccines, bioinks and other proteins. We accomplish all of this via our CGMP 130,000 square foot facility in Bryan, TX.Just imagine what we can do together! We know great things happen when talent and opportunity cross paths. We are looking to hire exceptional people who have demonstrated track records of success. Our greatest scientific solution is bringing talented people together who have a passion for advancing plant-based biologics for our customers and the world.Apply now for our Sr. Scientist - Assay Development position and help bring the power of plants to the biopharmaceutical industry!Mission of the PositionThis position is responsible for the development, design, execution, and transfer of biological, biochemical, and molecular assays to support product development, process characterization, and early stage production of biotherapeutic molecules. The Sr. Scientist-Assay Development develops and implements assay strategies for screening biological targets, characterization of in process samples, and ultimately transfers these assays to Quality Control for testing of final manufactured products.Essential Duties & Responsibilities* Develop and qualify assays for the identification, optimization, and characterization of recombinantly produced therapeutics (i.e. release assays)* Development/adaptation of assays for comparisons with innovator therapeutics* Grow, maintain, and generate (if necessary) target cell lines for use in cell-based assays for determining activity and potency of recombinant drugs including those made from a plant-based expression platform* Develop and standardize fluorescent, chemiluminescent, and flow cytometric based assays* Operation and maintenance of the in-house biosafety level 2 (BSL-2) facility* Acquire and maintain required analytical instrumentation, reagents, and supplies for molecular, protein, and cell-based activity assays* Responsible for screening operations (including scheduling), assay performance, and data flow* Responsible for assay development, validation, and implementation to support activities essential for drug development and manufacturing* Provide technical information and experimental assay design for recombinant product screening* Develop efficient operational models involving assay instrumentation, design, and analysis to streamline the workflow* Collect and interpret data for biological characterization assays and comparative studies; assist with data preparation for analysis and reporting* Help provide required trainings and maintain current knowledge of industry standards. May direct and oversee experimental design and results of associates and technicians.* Collaborate with members of the Early Stage Product Development Groups (Molecular Biology and Process Development), Manufacturing, Quality Control, and Quality Assurance* Develop screening protocols for all types of cell-based assays* Participate in evaluation of therapeutic technologies* Assist in the preparation and presentation of clear technical reports, publications, and oral presentationsKnowledge, Skills, & Abilities* Ability to make decision and recommendations* Ability to demonstrate professionalism with personnel and management* Collaborative team player* Ability to gather, organize, and analyze information skillfully* Ability to lead effectively* Strong foundation in experimental design and ability to execute complex experiments* Knowledge of post-transactional protein modifications including glycobiology* Must be able to communicate effectively through oral and written communicationEducation & Experience* Preferred Ph.D. and/or 10 years' experience in molecular biology techniques and experience in developing biochemical and cellular assays, especially Enzyme-Linked Immunosorbent Assays (ELISA) type assays* Experience in a cGMP regulated environment is required* Knowledge of laboratory safety protocols* Knowledge of plant-transient expression systems* Knowledge of standard analytical techniques, including SDS-PAGE, ELISA, and Western blot* Knowledge of optical methods* Knowledge and experience of screening reagent, and design of novel assays* Skill in documentation and attention to detail* Skill in computer functions such as word processors, spreadsheets, data visualization, cell sorting, FACS, Biacore and basic internet usage Associated topics: biopharma, dietetic, food scientist, histologist, histology, histotechnologist, industrial hygienist, medicine, pharmacy, physiologist

Keywords: IBIO, Bryan , Sr. Scientist - Assay Development, Other , Bryan, Texas

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